Researchers in this trial are trying to find better ways of treating platinum-resistant ovarian cancer. Platinum resistance means your cancer no longer responds to platinum-based chemotherapy (e.g. carboplatin). Strong evidence suggests that cortisol, a hormone in your body, can affect how well certain cancer treatments work. Scientists have fou…

In this study, researchers want to find out how safe and effective it is to use two new drugs, alone or in combination, to treat recurrent, low grade serous ovarian cancer (LGSOC).The drugs used in this trial are both a type of drug called a kinase inhibitor. Kinase inhibitors block cancer cell growth.The drugs involved in this trial are:Defactinib…

The purpose of this study is to determine if a combination of two different anti-cancer drugs are safe and effective in treating different types of solid tumours, including ovarian cancer. It's for women with ovarian cancer whose cancer has continued to spread and grow despite standard chemotherapy treatments. The drugs involved in this trial are k…

The purpose of this trial is to find out how safe and effective it is to have either one or two immunotherapy drugs alongside the parp inhibitor Rucaparib. Researchers want to find out if using the different combination of drugs will prolong the time it takes for your cancer to come back compared with being treated with Rucaparib on its own. The…

Recruitment to this trial is currently paused. The researchers in this trial are looking to find how out how well the drug ceralasertib (on its own) and the combination of the drugs ceralasertib and olaparib work in rarer types of gynaecological cancers. The drugs used in this clinical trial are: Ceralasertib is a drug called an ATR inh…

The main purpose of conducting the trial is to: determine the safety of combining cediranib, a VEGF inhibitor, with paclitaxel a weekly chemotherapy regime find out how well the treatment works in terms of shrinking the cancer and preventing bowel obstruction. If the cancer responds to this treatment then after the course of paclitaxel…

This trial looks to answer the question as to whether two different types of anti-cancer drugs, given as maintenance treatment are: safe effective well-tolerated Maintenance treatment is a type of targeted therapy that is given to try to prevent or delay the cancer's return after it has responded to chemotherapy. …