A researcher looking into a microscope whilst wearing protective eye wear with her colleague watching

FORECEE: Female cancer prediction using cervical omics to individualise screening and prevention

Trial at a glance

Open trial

  • Cancer type: Prevention/BRCA
  • Treatment stage: Prevention or diagnosis
  • Acronym: FORECEE

FORECEE: Female cancer prediction using cervical omics to individualise screening and prevention

Who can take part

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.


You may be eligible to take part in the study if you:

  • are a member of the public without any specific diagnosis
  • are planning to undergo breast or pelvic surgery unrelated to cancer
  • have been found to have abnormal cells on your cervix
  • have just been diagnosed with either breast, ovarian or endometrial cancer or where the doctor suspects a cancer diagnosis
  • have inherited a faulty gene (in BRCA1, BRCA2 or Lynch syndrome genes) that put you at a higher risk of developing one of the female-specific cancers

About the trial

The FORECEE (4C) research project is a new major study investigating the risk of breast, ovarian, womb and cervical cancer. Women who volunteer to take part in the study will be asked to donate the following samples:

  1. A blood sample
  2. A cheek swab
  3. A cervical smear sample
  4. Surplus healthy or diseased tissue – if you opt for risk-reducing surgery (that is, removal of both ovaries and tubes, or both breasts) the research team would want to analyse your tissues after the usual microscopic analyses have been performed.

You will also be asked to complete a questionnaire that will include questions about your medical, reproductive history and general health, history of cancer in the family and any symptoms that you may have experienced.

The samples donated are the main focus of the research. Hormones are known to drive the development of particular diseases in women.

Cervical cells are sensitive to the body’s own hormone levels in ways that are similar to the breast and other reproductive organs. This means that cervical cells may contain vital information about a woman’s risk of developing not just cervical disease, but other diseases that are hormone-responsive.

Buccal cells (cells collected from the cheek swab) are very similar to cervical cells but not hormone-sensitive and hence serve as ‘control cells’ with which we can compare the cervical cells.

Finally, blood cells reflect the immune system, which is also important in cancer development.

Studying tissues at risk (breast, ovary, tubes, the womb lining) will allow the research team to design specific preventive measures.