PArp Inhibitor Resistance Study (PAIRS)
Who can take part
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
You may be able to take part in this trial if you:
- are at least 16 years old
- have epithelial ovarian, primary peritoneal cancer or fallopian tube cancer that is of high grade type
- have a sample of tissue available and are willing to donate it
- have had treatment with a PARP inhibitor (for more than 3 months) or are going to start having treatment with a PARP inhibitor
This is not an exhaustive list. If you're interested in participating in a clinical trial, you should speak to your doctor about what other criteria might apply.
About the trial
In this study researchers are trying to find out why certain cancers stop responding to treatment with the class of drugs called PARP inhibitors.
PARP inhibitors are a type of targeted cancer drug. For some women PARP inhibitors stop working and this is known as becoming resistant. Researchers want to collect samples of blood and tumour to find out why this happens.
If you take part in this study you will be asked to donate blood and/or tissue samples
- before you start taking a PARP inhibitor
- after you finish having a PARP inhibitor
The research team plan to use the samples to:
- find out if there are any gene changes (mutations) in your cancer cells
- look for biomarkers that might help them to understand why PARP inhibitors work for some people and not others
This study is a sample collection study. You shouldn’t have any extra hospital visits if you take part.
This information was last reviewed on 28/02/2024. Please note that the status of clinical trials can change at short notice. You should always check with your clinical team which trials may be suitable for your situation.
