Clinical trial tag: Olaparib

 

Two nurses discussing patient notes in a chemotherapy unit
Closed trial

OLALA: An observational study of long-term responders to olaparib

Researchers in this study are trying to find out more about the mechanisms of action of a drug called olaparib. olaparib is a PARP inhibitor which is a targeted treatment for ovarian cancer. Researchers wish to find out why some women's ovarian cancer responds well to olaparib while other ovarian cancers don't. This information will help them to be…

A nurse talking and smiling with a woman during chemotherapy
Closed trial

ATARI: A trial looking at the drugs ceralasertib and olaparib for rarer gynaecological cancers

Recruitment to this trial is currently paused. The researchers in this trial are looking to find how out how well the drug ceralasertib (on its own) and the combination of the drugs ceralasertib and olaparib work in rarer types of gynaecological cancers. The drugs used in this clinical trial are: Ceralasertib is a drug called an ATR inh…

Closed trial

OCTOVA: A trial of olaparib and cediranib in recurrent ovarian cancer

This trial is looking to find better treatments for women with ovarian cancer that has come back. The trial is looking to find out if the drugs olaparib and cediranib are safe and work better than the standard chemotherapy drug paclitaxel. The drugs involved in this trial are: Paclitaxel – the known drug. This is a chemotherapy drug given …

Closed trial

MOLTO: A trial looking at second course olaparib in BRCA positive recurrent ovarian cancer

Olaparib is a type of targeted treatment known as a PARP inhibitor. It blocks an enzyme called PARP, which helps damaged cancer cells to repair themselves. When PARP doesn't work the cancer cells won't be able to repair themselves and will die. Because of this, drugs such as olaparib are known to lengthen the amount of time between receiving chemot…

Close up of a woman looking at Target Ovarian Cancer's website on her phone during chemotherapy
Closed trial

CEBOC: A study into the safety of cediranib in the prevention of bowel perforation

The main purpose of conducting the trial is to: determine the safety of combining cediranib, a VEGF inhibitor, with paclitaxel a weekly chemotherapy regime find out how well the treatment works in terms of shrinking the cancer and preventing bowel obstruction. If the cancer responds to this treatment then after the course of paclitaxel…

Close up of two people with painted nails holding hands
Closed trial

ICON9: A study of olaparib and cediranib in recurrent ovarian cancer

This trial looks to answer the question as to whether two different types of anti-cancer drugs, given as maintenance treatment are: safe effective well-tolerated Maintenance treatment is a type of targeted therapy that is given to try to prevent or delay the cancer's return after it has responded to chemotherapy. …