Purple bottle with white pills spilling out of it

Breakthrough in ovarian cancer treatment with niraparib 

Gamechanging drug could benefit thousands of women with advanced ovarian cancer every year.

From today, gamechanging treatment niraparib (Zejula®) will be available to newly diagnosed women with advanced ovarian cancer for the first time. Niraparib is a type of drug called a PARP inhibitor and works by stopping cancer cells from repairing themselves. 

Today’s landmark announcement from the National Institute for Health and Care Excellence (NICE) means that women with advanced ovarian cancer, regardless of whether they have a BRCA mutation, will be able to access a PARP inhibitor from their first line of treatment. This adds up to thousands of newly diagnosed women – a first in ovarian cancer. 

Why is this important? 

At the moment, the majority of women are diagnosed once the cancer has already spread, making it harder to treat and more likely to come back. Up until now, niraparib was only available to people whose cancer had come back (recurrent ovarian cancer). Accessing ovarian cancer drugs earlier means there’s a better chance of surviving ovarian cancer from the outset.  

Annwen Jones OBE, Chief Executive of Target Ovarian Cancer, said: 

Today’s announcement is a major milestone in the fight against ovarian cancer. With two thirds of women unfortunately diagnosed with later stage disease, it is absolutely crucial that more effective treatments are available. This is the biggest breakthrough in ovarian cancer drugs since the introduction of the chemotherapy drug paclitaxel – Taxol – in the 1990s.

Lyndsey Hadden, 64 from Enfield, has been taking niraparib since November 2019. She said: 

I was diagnosed four years ago and started taking niraparib after the ovarian cancer spread to my brain. After two brain surgeries and further radiotherapy, niraparib has given me another lease of life. It's much less harsh than some other treatments and I'm doing really well. It meant I could get back to my life including doing yoga, walking and swimming (when lockdown permits!)

Lyndsey - a woman with ovarian cancer who shared her story with Target Ovarian Cancer

Who will be able to access this treatment?  

It'll be available women with advanced (stage III or IV) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer after response to first-line platinum-based chemotherapy.  

It's being made available on the Cancer Drugs Fund in England and will be made available on the same basis in Wales and Northern Ireland. Scotland follows a different procedure for approving new treatments – niraparib for first-line treatment is currently under consideration by the Scottish Medicines Consortium and we'll bring updates as soon as we have them. 

What was Target Ovarian Cancer’s role?  

We've always championed better access to new cancer drugs. We played an active role in the NICE appraisal process by submitting evidence and acting as the patient expert at NICE committee meetings. If you'd like to find out more about our campaigns for improved treatment, join our campaigns network.